Eisosomes and Plasma Membrane Organization
نویسندگان
چکیده
منابع مشابه
Eisosomes promote the ability of Sur7 to regulate plasma membrane organization in Candida albicans
The plasma membrane of the fungal pathogen Candida albicans forms a protective barrier that also mediates many processes needed for virulence, including cell wall synthesis, invasive hyphal morphogenesis, and nutrient uptake. Because compartmentalization of the plasma membrane is believed to coordinate these diverse activities, we examined plasma membrane microdomains termed eisosomes or membra...
متن کاملHow eisosomes help the plasma membrane get organized
K arotki et al. (1) reveal how two proteins found in structures called eisosomes enable a yeast cell to parcel its plasma membrane into specialized domains. These proteins wind into helices and stick to the membrane, bending a portion of it into shape. Researchers agree that the proteins and lipids in the plasma membrane can sort into domains that perform particular functions such as signaling....
متن کاملEisosomes provide membrane reservoirs for rapid expansion of the yeast plasma membrane.
Cell surface area rapidly increases during mechanical and hypoosmotic stresses. Such expansion of the plasma membrane requires 'membrane reservoirs' that provide surface area and buffer membrane tension, but the sources of this membrane remain poorly understood. In principle, the flattening of invaginations and buds within the plasma membrane could provide this additional surface area, as recen...
متن کاملEvolutionarily Conserved 5’-3’ Exoribonuclease Xrn1 Accumulates at Plasma Membrane-Associated Eisosomes in Post-Diauxic Yeast
Regulation of gene expression on the level of translation and mRNA turnover is widely conserved evolutionarily. We have found that the main mRNA decay enzyme, exoribonuclease Xrn1, accumulates at the plasma membrane-associated eisosomes after glucose exhaustion in a culture of the yeast S. cerevisiae. Eisosomal localization of Xrn1 is not achieved in cells lacking the main component of eisosome...
متن کاملEisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium.
Eisosomes are plasma membrane domains concentrating lipids, transporters, and signaling molecules. In the budding yeast Saccharomyces cerevisiae, these domains are structured by scaffolds composed mainly by two cytoplasmic proteins Pil1 and Lsp1. Eisosomes are immobile domains, have relatively uniform size, and encompass thousands of units of the core proteins Pil1 and Lsp1. In this work we use...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.1386